| Person | Type | Job | Role(s) |
|---|---|---|---|
 Andrew Lazar | Crew | Production | Producer |
Bob Camp | Crew | Writing | Storyboard |
 Bruce Berman | Crew | Production | Executive Producer |
 Chris Bender | Crew | Production | Executive Producer |
 Christopher DeFaria | Crew | Production | Producer |
 Craig Barron | Crew | Visual Effects | Visual Effects Supervisor |
Craig Perry | Crew | Production | Producer |
 Glenn Ficarra | Crew | Writing | Screenplay |
 J.C. Spink | Crew | Production | Executive Producer |
 J.J. Makaro | Crew | Crew | Stunt Coordinator |
 James D. Bissell | Crew | Art | Production Design |
 John Debney | Crew | Sound | Original Music Composer |
 John Requa | Crew | Writing | Screenplay |
Julio Macat | Crew | Camera | Director of Photography |
Lawrence Guterman | Crew | Directing | Director |
 Mark A. Mangini | Crew | Sound | Supervising Dialogue Editor |
Michael A. Stevenson | Crew | Editing | Editor |
Rick Finney | Crew | Editing | Editor |
Tish Monaghan | Crew | Costume & Make-Up | Costume Design |
Warren Zide | Crew | Production | Producer |
Eric Oliver | Crew | Visual Effects | Animation |
John Slattery | Crew | Visual Effects | Digital Compositor |
 Alec Baldwin | Cast | Actor | Butch (voice) |
 Alexander Pollock | Cast | Actor | Scotty Brody |
 Alvin Sanders | Cast | Actor | Mason Employee |
 Billy West | Cast | Actor | Ninja Cat (voice) |
 Carol Ann Susi | Cast | Actress | Sophie's Sister |
 Charles Andre | Cast | Actor | Truck Driver |
 Charlton Heston | Cast | Actor | The Mastiff (voice) |
 Danny Mann | Cast | Actor | Ninja Cat (voice) |
 Doris Chillcott | Cast | Actress | Mrs. Calvert |
 Elizabeth Perkins | Cast | Actress | Mrs. Brody |
 Frank C. Turner | Cast | Actor | The Farmer |
 Frank Welker | Cast | Actor | Buddy (voice) |
 Gillian Barber | Cast | Actress | Factory Receptionist |
Glenn Ficarra | Cast | Actor | Russian Blue (voice) |
 Jeff Goldblum | Cast | Actor | Professor Brody |
 Joe Pantoliano | Cast | Actor | Peek (voice) |
 John Michael Higgins | Cast | Actor | Ginger Kitten (voice) |
 Jon Lovitz | Cast | Actor | Calico (voice) |
 Lauren K. Robek | Cast | Actress | Pie Mom (as Kirsten Robek) |
Lou Bollo | Cast | Worker | |
 Mark Schooley | Cast | Mason Employee | |
 Michael Clarke Duncan | Cast | Actor | Sam (voice) |
 Miriam Margolyes | Cast | Actress | Sophie the Castle Maid |
 Myron Natwick | Cast | Actor | Mr. Mason |
Pamela Perry | Cast | Actress | Yorkie Dog Owner |
 Paul Pape | Cast | Actor | Wolf Blitzer (voice) |
 Richard Steven Horvitz | Cast | Actor | Puppy in Barn (voice) |
 Salome Jens | Cast | Actress | Collie at HQ (voice) |
 Scott Nicholson | Cast | Actor | Worker |
 Sean Hayes | Cast | Actor | Mr. Tinkles (voice) |
 Susan Sarandon | Cast | Actress | Ivy (voice) |
 Tobey Maguire | Cast | Actor | Lou the Beagle (voice) |
Trish Schill | Cast | Actress | Worker |
Victor Wilson | Cast | Doberman Drill Sergeant (voice) | |
 Mar Andersons | Cast | Guard at Gate | |
Peggy Logan | Cast | Actress | Nurse |
Randi Kaplan | Cast | Actress | Sophie's Sister |
Mary Bogue | Cast | Actress | Sophie's Sister |
Alicia Michelle | Cast | Actress | Jogger |
Babe Dolan | Cast | Wife Passenger | |
Reg Glass | Cast | Truck Driver (as Reginald Glass) | |
| Person | Type | Job | Role(s) |
