| Person | Type | Job | Role(s) |
|---|---|---|---|
 Mo Willems | Crew | Writing | Writer, Story |
 Tom Warburton | Crew | Directing | Director, Creator, Story |
Maurice Joyce | Crew | Visual Effects | Animation Manager |
Alison Wilgus | Crew | Writing | Story |
Guy Moore | Crew | Directing | Director |
 Ben Diskin | Cast | Actor | Nigel 'Numbuh 1' Uno / Hoagie Pennywhistle 'Numbuh 2' Gilligan Jr / Numbuh 101 (voice) |
 Cam Clarke | Cast | Actor | Additional Voices (voice) |
 Candi Milo | Cast | Actress | Additional Voices (voice) |
 Cree Summer | Cast | Actress | Abigail 'Numbuh 5' Lincoln / Former Numbuh 11 - Cree Lincoln (voice) |
 Daran Norris | Cast | Actor | Count Spankulot (voice) |
 Dee Bradley Baker | Cast | Actor | Wally 'Numbuh 4' Beatles / Mr. Fibb / Toilenator / Joaquin / Tommy Gilligan (voice) |
 Frank Welker | Cast | Actor | Monty Uno (voice) |
 Grey DeLisle | Cast | Actress | Crazy Old Cat Lady/Gramma Stuffum (voice) |
 Janice Kawaye | Cast | Actress | Sonya - Number 83 / Lee - Numbuh 84 (voice) |
 Jeff Bennett | Cast | Actor | Mr. Boss / Mr. Fizz / Benedict Wigglestein (voice) |
 Jennifer Hale | Cast | Actress | Fanny 'Numbuh 86' Fulbright / Computer (voice) |
 Lauren Tom | Cast | Actress | Kuki 'Numbuh 3' Sanban (voice) |
 Mark Hamill | Cast | Actor | Stickybeard (voice) |
 Matt Levin | Cast | Actor | Patton 'Numbuh 60' Drilovsky (voice) |
 Maurice LaMarche | Cast | Actor | Father (voice) |
 Neil Ross | Cast | Actor | Grandfather (voice) |
 Ogie Banks | Cast | Actor | Sector Z Numbuh 0.1 - Bruce (voice) |
 Tom Kenny | Cast | Actor | Knightbrace / Mr. Wink (voice) |
 Rachael MacFarlane | Cast | Actress | Rachael T. 'Numbuh 362' McKenzie (voice) |
 Jason Harris | Cast | Actor | Chad Dickson (voice) |
 Dave Wittenberg | Cast | Actor | Numbuh Zero / Lenny - Sector Z Numbuh 0.4 (voice) |
| Person | Type | Job | Role(s) |
