| Person | Type | Job | Role(s) |
|---|---|---|---|
 Alan Crosland | Crew | Directing | Director |
 Ben Carré | Crew | Art | Art Direction |
 Bess Meredyth | Crew | Writing | Screenplay |
 Byron Haskin | Crew | Camera | Director of Photography |
 David Mendoza | Crew | Sound | Original Music Composer |
Duke Green | Crew | Crew | Stunts |
Gordon Hollingshead | Crew | Directing | Assistant Director |
Harold McCord | Crew | Editing | Editor |
William Axt | Crew | Sound | Original Music Composer |
Gerald W. Alexander | Crew | Sound | Sound |
 Dick Sutherland | Cast | Actor | Gentleman of Rome (uncredited) |
 Emily Fitzroy | Cast | Actress | The Dowager (uncredited) |
 Estelle Taylor | Cast | Lucrezia Borgia | |
 Gibson Gowland | Cast | Actor | Gentleman of Rome (uncredited) |
 Gustav von Seyffertitz | Cast | Actor | Neri - the Alchemist (uncredited) |
 Hedda Hopper | Cast | Actress | Marchesia Rinaldo |
 Helen Lee Worthing | Cast | Eleanora (uncredited) | |
 Helena D'Algy | Cast | Actress | Donna Elvira (uncredited) |
 Helene Costello | Cast | Actress | Rena - Adriana's Maid (uncredited) |
 Jane Winton | Cast | Actress | Donna Isobel |
 John Barrymore | Cast | Actor | Don Jose de Marana / Don Juan de Marana |
 John George | Cast | Actor | Hunchback (uncredited) |
 John Roche | Cast | Actor | Leandro |
 Josef Swickard | Cast | Actor | Duke Della Varnese |
 June Marlowe | Cast | Actress | Trusia (uncredited) |
 Lionel Braham | Cast | Actor | Duke Margoni (uncredited) |
 Mary Astor | Cast | Actress | Adriana della Varnese |
 Montagu Love | Cast | Actor | Count Giano Donati |
 Myrna Loy | Cast | Actress | Mai - Lady in Waiting |
 Nigel De Brulier | Cast | Actor | Marchese Rinaldo |
 Philippe De Lacy | Cast | Actor | Don Juan - at age 10 (uncredited) |
 Phyllis Haver | Cast | Actress | Imperia (uncredited) |
 Sheldon Lewis | Cast | Actor | Gentleman of Rome (uncredited) |
 Warner Oland | Cast | Actor | Cesare Borgia |
 Willard Louis | Cast | Actor | Pedrillo |
Jacob Dance | Cast | Gentleman (uncredited) | |
Yvonne Day | Cast | Don Juan - at age 5 (uncredited) | |
| Person | Type | Job | Role(s) |
