| Person | Type | Job | Role(s) |
|---|---|---|---|
 Amy Heckerling | Crew | Directing | Director, Writer |
 David Kitay | Crew | Sound | Original Music Composer |
Debra Chiate | Crew | Editing | Editor |
 Jack Gill | Crew | Crew | Stunts |
 Jonathan D. Krane | Crew | Production | Producer |
Thomas Del Ruth | Crew | Camera | Director of Photography |
 Abe Vigoda | Cast | Actor | Grandpa |
 Alex Bruhanski | Cast | Actor | Street Worker |
Andrea Mann | Cast | Actress | Salesgirl |
 Aurelio Dinunzio | Cast | Actor | Orderly |
 Blu Mankuma | Cast | Actor | Director |
 Brenda Crichlow | Cast | Actress | Secretary |
 Bruce Willis | Cast | Actor | Mikey (voice) |
Casey Grant | Cast | Actor | Admitting Clerk |
 Dee Jay Jackson | Cast | Actor | Burly Orderly |
 Deryl Hayes | Cast | Actor | Pilot Friend |
 Don S. Davis | Cast | Actor | Dr. Fleischer |
Enid Saunders | Cast | Actress | Ester |
 George Segal | Cast | Actor | Albert |
 Gerry Bean | Cast | Actor | Pilot Friend |
 Jerry Wasserman | Cast | Actor | Mr. Anal |
 Joan Rivers | Cast | Actress | Julie (voice) (uncredited) |
 John Travolta | Cast | Actor | James Ubriacco |
 Joy Boushel | Cast | Actress | Melissa |
 Kirstie Alley | Cast | Actress | Mollie Jensen |
 Mollie Heckerling | Cast | Actress | Little Girl |
 Neal Israel | Cast | Actor | Mr. Ross |
Nicholas Rice | Cast | Actor | Harry |
 Olympia Dukakis | Cast | Actress | Rosie |
 Twink Caplan | Cast | Actress | Rona |
 William B. Davis | Cast | Actor | Drug Doctor |
 Jacob Haines | Cast | Mikey (age 1) | |
David Berner | Cast | Actor | Mr. Impatience |
Jaryd Waterhouse | Cast | Mikey (newborn) | |
Daliah Novak | Cast | Actress | Carrie |
Zena Darawalla | Cast | Actress | Lupe |
Douglas Tuck | Cast | Cab Stealer | |
Jeff Irvine | Cast | Actor | Admitting Doctor |
Michael Joseph Materi | Cast | Actor | Nursery Baby |
Nigel John Crowe | Cast | Actor | Nursery Baby |
Ariel Perryman | Cast | Actress | Nursery Baby |
Sabrina Bailey | Cast | Actress | Sand Box Baby |
Christy Smith | Cast | Actress | Baby Megan |
Nicole Stevens | Cast | Actress | Silly Baby |
Ryan McIntosh | Cast | Actor | Little Boy |
Eleanor Maines | Cast | Actress | Lady |
Bea Cartmell | Cast | Actress | Lady |
Ida Berner | Cast | Actress | Lady |
William Britos | Cast | Actor | Home Orderly |
Shirley Barclay | Cast | Actress | Nurse |
Louis Heckerling | Cast | Actor | Lou |
Christopher Aydon | Cast | Actor | Mikey |
Jason Schaller | Cast | Actor | Mikey |
Amber Brownmiller | Cast | Actress | Blowing Kiss Baby |
Oscar B. Ramos | Cast | Actor | Hospital Worker |
Farah Abassi | Cast | Actress | Chatting Baby |
| Person | Type | Job | Role(s) |
