| Person | Type | Job | Role(s) |
|---|---|---|---|
 Aaron Parry | Crew | Production | Associate Producer |
Adam Beck | Crew | Visual Effects | Animation |
Arlan Jay Vetter | Crew | Art | Art Direction |
Audrey Stedman | Crew | Directing | Layout |
Barry Caldwell | Crew | Writing | Storyboard |
Bob Camp | Crew | Writing | Storyboard |
 Bobby Farrelly | Crew | Directing | Director, Producer |
 Bradley Thomas | Crew | Production | Producer |
Brenda McNally | Crew | Costume & Make-Up | Hair Department Head |
Carol Koch | Crew | Art | Sculptor |
Chris Aguirre | Crew | Visual Effects | Visual Development |
Craig R. Maras | Crew | Visual Effects | Animation |
Daan Jippes | Crew | Writing | Storyboard |
Darek Gogol | Crew | Visual Effects | Visual Development |
Darlie Brewster | Crew | Crew | Supervising Animator |
Dennis Edwards | Crew | Production | Producer |
Earl A. Hibbert | Crew | Visual Effects | Visual Effects |
Eddie Rosas | Crew | Visual Effects | Animation |
Fred Cline | Crew | Visual Effects | Visual Development |
Hal Olofsson | Crew | Directing | First Assistant Director |
James P. Alles | Crew | Directing | Layout |
Jeannine Berger | Crew | Crew | Post Production Supervisor |
Jeff Etter | Crew | Visual Effects | Visual Development |
Jennifer Yuan | Crew | Directing | Layout |
Joe Giampapa | Crew | Visual Effects | Animation |
Joe Rossi | Crew | Costume & Make-Up | Makeup Department Head |
John Bermudes | Crew | Crew | Special Effects |
John Harajovic | Crew | Crew | Special Effects |
 John Walker | Crew | Production | Associate Producer |
John Williamson | Crew | Visual Effects | Animation |
Karen Hamrock | Crew | Directing | Layout |
Kevin Johnson | Crew | Visual Effects | Visual Development |
 Leon Delaney | Crew | Crew | Stunt Coordinator |
Lois Freeman-Fox | Crew | Editing | Editor |
 Louis Gonzales | Crew | Directing | Layout |
Marc Hyman | Crew | Writing | Screenplay |
Marc S. Fischer | Crew | Production | Co-Producer |
 Mark Andrews | Crew | Writing | Storyboard |
 Mark Irwin | Crew | Camera | Director of Photography |
Pamela Withers | Crew | Costume & Make-Up | Costume Design |
 Peter Farrelly | Crew | Directing | Director, Producer |
 Randy Edelman | Crew | Sound | Original Music Composer |
 Randy Thom | Crew | Sound | Sound Designer |
Ricardo F. Delgado | Crew | Visual Effects | Visual Development |
Rick Montgomery | Crew | Production | Casting |
 Ruben Chavez | Crew | Visual Effects | Visual Development |
Sam Seig | Crew | Editing | Editor |
Scott Jacobson | Crew | Art | Set Decoration |
Shane Prigmore | Crew | Visual Effects | Animation |
Stephan Franck | Crew | Visual Effects | Lead Animator |
 Stephen Schaffer | Crew | Editing | Editor |
Steven Burch | Crew | Visual Effects | Special Effects Supervisor |
Sydney J. Bartholomew Jr. | Crew | Art | Production Design |
William 'Billy Jack' Jakielaszek | Crew | Crew | Special Effects Coordinator |
 Zak Penn | Crew | Production | Producer |
Hani D. El-Masri | Crew | Visual Effects | Visual Development |
Ian Mah | Crew | Visual Effects | Visual Effects Supervisor |
Katherine C. Concepcion | Crew | Art | Art Department Manager |
Randy Sanchez | Crew | Visual Effects | Animation |
Sam Chou | Crew | Visual Effects | Animation |
Steve Fonti | Crew | Writing | Storyboard |
Paul Dutton | Crew | Visual Effects | Animation |
Ken Ross | Crew | Sound | Music Supervisor |
Bill Perkins | Crew | Directing | Layout |
 Moroni Taylor | Crew | Art | Storyboard Artist |
 Bill Murray | Cast | Actor | Frank Detorre |
 Brandy Norwood | Cast | Actress | Leah (voice) |
 Carlos Alazraqui | Cast | Actor | Additional Character Voices (voice) |
 Chris Elliott | Cast | Actor | Bob |
 Chris Rock | Cast | Actor | Osmosis Jones (voice) |
 Danny Mann | Cast | Actor | Additional Character Voices (voice) |
 David Hyde Pierce | Cast | Actor | Drix (voice) |
 Elena Franklin | Cast | Actress | Shane Detorre |
 Jonathan Adams | Cast | Actor | Additional Character Voices (voice) |
 Kid Rock | Cast | Actor | Kidney Rock |
 Laurence Fishburne | Cast | Actor | Thrax (voice) |
 Mickie McGowan | Cast | Actress | Additional Character Voices (voice) |
 Molly Shannon | Cast | Actress | Mrs. Boyd |
 Richard Steven Horvitz | Cast | Actor | Additional Character Voices (voice) |
 Rodger Bumpass | Cast | Actor | Additional Character Voices (voice) |
 Ron Howard | Cast | Actor | Tom Colonic (voice) |
 Sherry Lynn | Cast | Actress | (voice) |
 William Shatner | Cast | Actor | Mayor Phlegmming (voice) |
| Person | Type | Job | Role(s) |
