| Person | Type | Job | Role(s) | Episodes |
|---|---|---|---|---|
 Mike Drucker | Crew | Writing | Writer | 25 |
Nick Murray | Crew | Directing | Director | 1 |
 Alton Brown | Cast | Actor | Himself | 1 |
 Bill Nye | Cast | Actor | Himself - Host | 25 |
 Diedrich Bader | Cast | Actor | Smallpox | 1 |
 George Wendt | Cast | Actor | Polio | 1 |
 Heather McDonald | Cast | Actress | Beef | 1 |
 Jim O'Heir | Cast | Actor | Rabies | 1 |
 John O'Hurley | Cast | Actor | Influenza | 1 |
 Margaret Cho | Cast | Actress | Pistachio (voice) | 1 |
 Mario Cantone | Cast | Actor | Strawberry (voice) | 1 |
 Martin Starr | Cast | Actor | Doug the Caveman | 1 |
 Matt Lucas | Cast | Actor | Salted Caramel (voice) | 1 |
 Sandra Bernhard | Cast | Actress | Mint Choc Chip (voice) | 1 |
 Todd Barry | Cast | Actor | Vanilla (voice) | 1 |
 Tracy Mann | Cast | Actress | Herself - Panelist | 1 |
 Wil Wheaton | Cast | Actor | Himself - Panelist | 1 |
 Zach Braff | Cast | Actor | Himself | 1 |
Cece Pleasants | Cast | HPV | 1 | |
 Geoff Ramsey | Cast | Actor | Rooster Teeth | 1 |
 Gus Sorola | Cast | Actor | Rooster Teeth | 1 |
 Neil deGrasse Tyson | Cast | Actor | Voice of Coffee Maker | 1 |
 Randy Couture | Cast | Actor | Tardigrade | 1 |
 Tim Gunn | Cast | Actor | Himself | 1 |
 Lauren Ash | Cast | Actress | Kale | 1 |
 Steve Aoki | Cast | Actor | Himself | 1 |
 Karlie Kloss Kushner | Cast | Actress | Herself - Correspondent | 3 |
Nazeem Hussain | Cast | Actor | Himself - Correspondent | 2 |
 Rachel Bloom | Cast | Actress | Martian | 1 |
 Aubrey Anderson-Emmons | Cast | Actress | The Director | 1 |
 Cameron Esposito | Cast | Actress | Chocolate (voice) | 1 |
 Emily Calandrelli | Cast | Actress | Herself - Correspondent | 2 |
 Desiigner | Cast | Actor | Himself | 1 |
 Jeff Dye | Cast | Actor | Eggplant | 1 |
 Taryn O'Neill | Cast | Herself - Panelist | 1 | |
 Derek Muller | Cast | Actor | Himself - Correspondent | 5 |
 Andi Osho | Cast | Actress | Bread | 1 |
Prof. Mark Jacobson | Cast | Himself - Panelist | 1 | |
 Sara Benincasa | Cast | Actress | Herself - Panelist | 1 |
 Cara Santa Maria | Cast | Actress | Herself - Panelist | 1 |
Joanna Hausmann | Cast | Actress | Herself - Correspondent | 2 |
Julie Kennye | Cast | Herself - Panelist | 1 | |
Fred Gould | Cast | Himself - Panelist | 1 | |
Robb Fraley | Cast | Himself - Panelist | 1 | |
Jennifer Widerstrom | Cast | Actress | Herself - Panelist | 1 |
Nicole Go | Cast | DJ Seahorse | 1 | |
Katrina Karkazis | Cast | Herself - Panelist | 1 | |
Jeffrey McCune Jr. | Cast | Himself - Panelist | 1 | |
Prashanth Venkataramanujam | Cast | Casting Director | 1 | |
Moogega Cooper | Cast | Actress | Herself - Panelist | 1 |
Andy Rossi | Cast | Tardigrade Victim | 1 | |
Marcus Lindsay | Cast | Tardigrade Victim | 1 | |
Chris Beedie | Cast | Himself - Panelist | 1 | |
Richard Martin | Cast | Himself - Panelist | 1 | |
Margaret Mitchell | Cast | Herself | 1 | |
Salim Shaikh | Cast | Himself | 1 | |
Sanden Totten | Cast | Ebola | 1 | |
Subbarao Kambhampati | Cast | Himself - Panelist | 1 | |
Xeji Jardin | Cast | Herself - Panelist | 1 | |
Ryan Calo | Cast | Himself - Panelist | 1 | |
Donald Schultz | Cast | Himself - Panelist | 1 | |
Jennifer Reich | Cast | Herself - Panelist | 1 | |
Kristen Omeara | Cast | Herself - Panelist | 1 | |
Lanre Falusi | Cast | Herself - Panelist | 1 | |
Rachel Snow | Cast | Herself - Panelist | 1 | |
Paul Knoepfler | Cast | Himself - Panelist | 1 | |
Nerys Benfield | Cast | Herself - Panelist | 1 | |
Camille Hammond | Cast | Herself - Panelist | 1 | |
Travis Rieder | Cast | Himself - Panelist | 1 | |
Hilarie Cash | Cast | Actress | Herself - Panelist | 1 |
Shawn Green | Cast | Himself - Panelist | 1 | |
Jonna Mae | Cast | Herself - Panelist | 1 | |
Leslie Hinkson | Cast | Herself - Panelist | 1 | |
 Hakeem Muata Oluseyi | Cast | Actor | Himself - Panelist | 1 |
| Person | Type | Job | Role(s) | Episodes |
