| Person | Type | Job | Role(s) | Episodes |
|---|---|---|---|---|
 Anya Epstein | Crew | Production | Executive Producer, Writer | 6 |
 Bonnie Timmermann | Crew | Production | Casting | 6 |
 Derek Cianfrance | Crew | Production | Executive Producer, Writer, Creator, Director | 6 |
 Glen Basner | Crew | Production | Executive Producer | 6 |
Gregg Fienberg | Crew | Production | Executive Producer | 6 |
 Harold Budd | Crew | Sound | Original Music Composer | 6 |
Jim Black | Crew | Sound | Music Supervisor | 6 |
Jim Helton | Crew | Editing | Editor | 6 |
 Kasia Walicka Maimone | Crew | Costume & Make-Up | Costume Design | 6 |
Leo Won | Crew | Costume & Make-Up | Makeup Department Head | 6 |
Malcolm Jamieson | Crew | Editing | Editor | 6 |
Mariusz Glabinski | Crew | Sound | Sound Designer | 6 |
 Mark Ruffalo | Crew | Production | Executive Producer | 6 |
Nico Leunen | Crew | Editing | Editor | 6 |
Tony Volante | Crew | Sound | Sound Re-Recording Mixer, Supervising Sound Editor | 6 |
Atsushi Nishijima | Crew | Camera | Still Photographer | 6 |
 Ben Browning | Crew | Production | Executive Producer | 6 |
 Inbal Weinberg | Crew | Art | Production Design | 6 |
 Jamie Patricof | Crew | Production | Co-Executive Producer | 6 |
 Jody Lee Lipes | Crew | Camera | Director of Photography | 6 |
 Lynette Howell Taylor | Crew | Production | Executive Producer | 6 |
Ron Patane | Crew | Editing | Editor | 6 |
Alison Ford | Crew | Art | Art Direction | 6 |
Daniel Timmons | Crew | Sound | Supervising Sound Editor, Dialogue Editor | 6 |
Wally Lamb | Crew | Production | Executive Producer, Novel | 6 |
Charles Christopher Rubino | Crew | Art | Title Designer | 6 |
Jeffrey T. Bernstein | Crew | Production | Producer | 6 |
Eleonora de Simone | Crew | Art | Assistant Art Director | 6 |
Diane Calfee | Crew | Costume & Make-Up | Makeup Artist | 6 |
 Dylan Hopkins | Crew | Directing | First Assistant Director | 1 |
Nicole Montagnino | Crew | Art | Set Decoration | 6 |
Michael C. Bolton | Crew | Production | Co-Producer | 6 |
Dean Palisch | Crew | Editing | Editor | 6 |
Marisia Moreno | Crew | Directing | Second Assistant Director | 1 |
 A.C. Peterson | Cast | Actor | Gene Diogenes | 1 |
 Archie Panjabi | Cast | Actress | Dr. Patel | 6 |
 Brian Goodman | Cast | Actor | Al | 1 |
 Bruce Greenwood | Cast | Actor | Dr. Hume | 2 |
 Federico Dordei | Cast | Actor | Nunzio Tucci | 1 |
 Felix Solis | Cast | Actor | Nurse | 1 |
 Guillermo Díaz | Cast | Actor | Sergeant Mercado | 1 |
 Harris Yulin | Cast | Actor | Father Lavie | 1 |
 James Quattrochi | Cast | Actor | Bus Driver | 1 |
 Joe Grifasi | Cast | Actor | Steve Falice | 1 |
 John Procaccino | Cast | Actor | Ray Birdsey | 6 |
 Joseph Ragno | Cast | Actor | Henrey Rood | 1 |
 Juliette Lewis | Cast | Actress | Nedra Frank | 2 |
 Kathryn Hahn | Cast | Actress | Dessa Constantine | 6 |
 Laura Esterman | Cast | Actress | Ruth Hood | 3 |
 Laura Silverman | Cast | Actress | Kristin | 1 |
Mark Ruffalo | Cast | Actor | Dominick Birdsey / Thomas Birdsey | 6 |
 Marylouise Burke | Cast | Actress | Librarian | 1 |
 Melissa Leo | Cast | Actress | Concettina Ipolita Tempesta 'Ma' Birdsey | 6 |
 Michael Genet | Cast | Actor | Thomas' Surgeon | 1 |
 Michael Greyeyes | Cast | Actor | Ralph Drinkwater | 6 |
 Rosie O'Donnell | Cast | Actress | Lisa Sheffer | 6 |
 Sandra Berrios | Cast | Actress | Social Worker at Hatch | 1 |
Tim Ruddy | Cast | Robocop | 1 | |
 Gabe Fazio | Cast | Actor | Shawn Tudesco / Dominick and Thomas Acting Double | 6 |
 Imogen Poots | Cast | Actress | Joy Hanks | 3 |
 Jason Furlani | Cast | Actor | Larry Penn | 1 |
 Rob Huebel | Cast | Actor | Leo | 6 |
 Sean Cullen | Cast | Actor | Dr. Yates | 1 |
 Shannon Plumb | Cast | Actress | Charlotte | 1 |
 Sue Jean Kim | Cast | Actress | Dr. Yup | 1 |
 Tatanka Means | Cast | Actor | Nabby Drinkwater | 2 |
Al Linea | Cast | Abruzzi | 1 | |
 Amy Lynn Stewart | Cast | Merciful Mother | 1 | |
 Katt Masterson | Cast | Doreen | 1 | |
 Philip Ettinger | Cast | Actor | Early Adulthood Dominick Birdsey / Thomas Birdsey | 2 |
 Thomas Gionet-Lavigne | Cast | Actor | Ray's Orderly | 1 |
 Aisling Franciosi | Cast | Actress | Young Dessa Constantine | 2 |
María Gonzalez | Cast | Ma's Oncology Nurse | 1 | |
Paul Coleman | Cast | Support Group Counselor | 1 | |
 Michael Simon Hall | Cast | Actor | Stuart Feinstein | 1 |
 MorningStar Angeline | Cast | Actress | Nabby Drinkwater's Wife | 1 |
 Marcello Fonte | Cast | Actor | Domenico Onofrio Tempesta | 2 |
Alexander Hacker | Cast | Templeton | 1 | |
 Gina Costigan | Cast | Actress | Mrs. O'Meara | 1 |
 Wayne J. Miller | Cast | Actor | Mourner Wayne | 1 |
Richard Fitch | Cast | Mill Foreman | 1 | |
 Steven Cox | Cast | Actor | Boyfriend of Dr. Hume's Daughter | 1 |
 Derek Goh | Cast | 17-19 Year Old Dominick & Thomas Acting Double | 2 | |
Annie Fitzgerald | Cast | Actress | Miss Hanker | 2 |
 Kate Grimes | Cast | Actress | English Professor | 1 |
 Jake Robards | Cast | Actor | Landlubbers (voice) | 1 |
 Simone Coppo | Cast | Actor | Vincenzo Tempesta | 1 |
 Destry Allyn Spielberg | Cast | Actress | Dr. Hume's Daughter | 1 |
 Christine Parks | Cast | Humanities Department Chair | 1 | |
Oliver Patnode | Cast | Otero | 2 | |
Zaria Degenhardt | Cast | Actress | 11 Year Old Concettina | 1 |
Raymond Neil Hernandez | Cast | Actor | Omar | 1 |
Robert Mladinich | Cast | Paddy Wagon Officer | 1 | |
 Chelsea Sheets | Cast | Actress | Brunette | 1 |
 Brandon J. Dirden | Cast | Actor | Kyle's Dad | 1 |
Morgan Sullivan | Cast | Actor | Office Buddy | 1 |
Rachel B. Joyce | Cast | Jeanette | 1 | |
Charles Reina | Cast | Channy | 2 | |
 Agatha Nowicki | Cast | Actress | Angie Constantine | 2 |
Mark A. Gamma | Cast | Mourner Mark | 1 | |
Acahkos Johnson | Cast | Penny Ann Drinkwater | 2 | |
Rocco Masihi | Cast | Young Thomas Birdsey | 4 | |
 Matt Helm | Cast | Actor | Young Leo | 2 |
 Jaiden Klein | Cast | Marie Sexton | 2 | |
Violet Adams | Cast | Actress | Bunny Borsa | 2 |
Adrienne R. Williams | Cast | Mrs. Birdsall | 2 | |
 Christopher J. Hanke | Cast | Thad | 1 | |
 Roberta Riganò | Cast | Ignazia Tempesta | 1 | |
| Person | Type | Job | Role(s) | Episodes |
