| Person | Type | Job | Role(s) | Episodes |
|---|---|---|---|---|
 Curt Geda | Crew | Directing | Director | 2 |
 Jay Oliva | Crew | Writing | Storyboard | 3 |
 Jed Elinoff | Crew | Writing | Writer | 1 |
Joe Ruby | Crew | Writing | Characters, Writer | 52 |
 Joseph Barbera | Crew | Writing | Characters | 52 |
Ken Spears | Crew | Writing | Characters | 52 |
Mitch Watson | Crew | Writing | Writer, Creator | 1 |
 Spike Brandt | Crew | Creator | Creator | |
 Tony Cervone | Crew | Creator | Creator | |
 Victor Cook | Crew | Directing | Director | 2 |
 William Hanna | Crew | Writing | Characters | 52 |
 Sam Register | Crew | Production | Producer | 52 |
Scott Thomas | Crew | Writing | Writer | 1 |
Chul-ho Kim | Crew | Crew | Other | 52 |
 Lauren Montgomery | Crew | Directing | Director | 4 |
 Amy Acker | Cast | Actress | Nova (voice) | 4 |
 April Winchell | Cast | Actress | Weena (voice) | 1 |
 Audrey Wasilewski | Cast | Actress | Queen Amanda (voice) | 1 |
 Beverly D'Angelo | Cast | Actress | Sheila Altoonian (voice) | 1 |
 Billy West | Cast | Actor | Randy Warsaw (voice) | 1 |
 Carlos Alazraqui | Cast | Actor | Ernesto (voice) | 2 |
 Casey Kasem | Cast | Actor | Colton Rogers (voice) | 5 |
 Charles Shaughnessy | Cast | Actor | Ned Fussbuster (voice) | 1 |
 Chris Hardwick | Cast | Actor | Maxwell (voice) | 1 |
 Christopher Corey Smith | Cast | Actor | Race Bannon (voice) | 1 |
 Clancy Brown | Cast | Actor | Hebediah Grim (voice) | 1 |
 Clyde Kusatsu | Cast | Actor | Picnicker (voice) | 1 |
 Cree Summer | Cast | Actress | Lady Marmalade (voice) | 1 |
 Crispin Freeman | Cast | Actor | Ben (voice) | 1 |
 Daran Norris | Cast | Actor | Skipper's Brother (voice) | 1 |
 Daryl Sabara | Cast | Actor | Jason (voice) | 1 |
 Dave Allen | Cast | Actor | Rick Yantz (voice) | 1 |
 David Faustino | Cast | Actor | Bud Coleman (voice) | 1 |
 David Kaye | Cast | Actor | Dad (voice) | 3 |
David Markus | Cast | Young Man / Ben (voice) | 1 | |
 Dee Bradley Baker | Cast | Actor | Slime Mutant / Franklin Fruitmeir (voice) | 1 |
 Dwight Schultz | Cast | Actor | Older Danny Darrow (voice) | 1 |
 Florence Henderson | Cast | Actress | Ruby Stone (voice) | 1 |
 Frances Conroy | Cast | Actress | Mrs. Dinkley (voice) | 1 |
 Frank Welker | Cast | Actor | Scooby-Doo / Fred Jones (voice) | 52 |
 Fred Tatasciore | Cast | Actor | Workman #2 (voice) | 1 |
 Gary Anthony Williams | Cast | Actor | Dr. Cavanaugh (voice) | 1 |
 Gary Cole | Cast | Actor | Mayor Fred Jones Sr. / Paramedic #2 (voice) | 1 |
 George Segal | Cast | Actor | Peter Trickell (voice) | 1 |
 George Takei | Cast | Actor | Mr. Wang / White Wizard (voice) | 1 |
 Greg Ellis | Cast | Actor | Charles 'Cachinga' Wheatlesby (voice) | 1 |
 Grey DeLisle | Cast | Actress | Francilee Jackson / Mrs. Feist / Paula Rogers (voice) | 1 |
 Harlan Ellison | Cast | Actor | Self (voice) | 2 |
 Heather North | Cast | Actress | 0 | |
 Hynden Walch | Cast | Actress | Alice May (voice) | 2 |
 James Arnold Taylor | Cast | Actor | Randy (voice) | 1 |
 James Hong | Cast | Actor | Chen / Red Wizard (voice) | 1 |
 James Marsters | Cast | Actor | Dandy Highwayman (voice) | 1 |
 James Patrick Stuart | Cast | Actor | Dr. Rick Spartan | 1 |
 Jane Wiedlin | Cast | Actress | Dusk (voice) | 2 |
 Jason Marsden | Cast | Actor | Horbert Feist (voice) | 1 |
 Jeff Bennett | Cast | Actor | Gary (voice) | 1 |
 Jeffrey Combs | Cast | Actor | H.P. Hatecraft (voice) | 2 |
 Jeffrey Tambor | Cast | Actor | Gill Littlefoot (voice) | 1 |
 Jennifer Hale | Cast | Actress | Delilah Blake / Mom (voice) | 1 |
 Jessica Walter | Cast | Actress | Jason's Mom (voice) | 1 |
 Jim Cummings | Cast | Actor | Captain Caveman (voice) | 1 |
 Jim Rash | Cast | Actor | J.R. Kipple (voice) | 1 |
 Joe Holt | Cast | Actor | Hugh Dederdee (voice) | 1 |
 John Billingsley | Cast | Actor | Dr. Henklefust (voice) | 1 |
 John DiMaggio | Cast | Actor | Grady Gator (voice) | 1 |
 John O'Hurley | Cast | Actor | Skipper Shelton (voice) | 8 |
 Julie Bowen | Cast | Actress | Marion Spartan (voice) | 1 |
 Kath Soucie | Cast | Actress | Nan Blake (voice) | 9 |
 Kevin Dunn | Cast | Actor | Dale Dinkley / Workman #1 (voice) | 1 |
 Kevin Michael Richardson | Cast | Actor | Hulking Red (voice) | 1 |
 Laraine Newman | Cast | Actress | Granny Snaggletooth (voice) | 1 |
 Lewis Black | Cast | Actor | Mr. E (voice) | 5 |
 Linda Cardellini | Cast | Actress | Hot Dog Water (voice) | 1 |
 Marion Ross | Cast | Actress | Grandma Moonbeam (voice) | 1 |
 Mark Hamill | Cast | Actor | Crybaby Clown (voice) | 2 |
 Martha Quinn | Cast | Actress | Self (voice) | 1 |
 Matthew Lillard | Cast | Actor | Shaggy Rogers (voice) | 52 |
 Maurice LaMarche | Cast | Actor | Vincent Van Ghoul (voice) | 6 |
 Michael J. Anderson | Cast | Actor | Professor Horatio Kharon (voice) | 2 |
 Mindy Cohn | Cast | Actress | Velma Dinkley (voice) | 52 |
 Mindy Sterling | Cast | Actress | Dean Fenk (voice) | 2 |
Mitch Watson | Cast | Actor | Farmer (voice) | 1 |
 Nicole Jaffe | Cast | Actress | 0 | |
 Nolan North | Cast | Actor | Brad Chiles (voice) | 2 |
 Patrick Warburton | Cast | Actor | Sheriff Bronson Stone (voice) | 34 |
 Paul Rugg | Cast | Actor | Kelsepsian (voice) | 1 |
 Phil LaMarr | Cast | Actor | Melvin Keisterbaum (voice) | 1 |
 Powers Boothe | Cast | Actor | Dead Justice (voice) | 1 |
 Quinton Flynn | Cast | Actor | Daniel Prezette / Fantzee Pantz / Gus Boggs (voice) | 1 |
 Richard McGonagle | Cast | Actor | Ed Machine (voice) | 4 |
 Rob Paulsen | Cast | Actor | Winslow Fleach (voice) | 1 |
 Roz Ryan | Cast | Actress | Gorgeous G (voice) | 1 |
 Scott Menville | Cast | Actor | Ricky Owens (voice) | 2 |
 Tia Carrere | Cast | Actress | Amy (voice) | 1 |
 Tim Matheson | Cast | Actor | Brad Chiles (voice) | 13 |
 Tom Kenny | Cast | Actor | Auctioneer (voice) | 1 |
Tony Cervone | Cast | Actor | Gary (voice) | 5 |
 Tricia Helfer | Cast | Actress | Aphrodite (voice) | 1 |
 Udo Kier | Cast | Actor | Professor Pericles (voice) | 17 |
 Vivica A. Fox | Cast | Actress | Cassidy Williams / Angel Dynamite (voice) | 2 |
 Ben McKenzie | Cast | Actor | Odnarb (voice) | 1 |
 Beth Tapper | Cast | Brenda (voice) | 3 | |
 Eric Bauza | Cast | Actor | Eager Clerk (voice) | 1 |
 Kari Wahlgren | Cast | Actress | Judy Reeves (voice) | 2 |
 Kate Higgins | Cast | Actress | Principal Quinlan (voice) | 1 |
 Kimberly Brooks | Cast | Actress | Cassidy Williams (voice) | 2 |
 Lloyd Sherr | Cast | Actor | Lord Barry (voice) | 1 |
 Matt Lanter | Cast | Actor | Baylor Hotner (voice) | 3 |
 Rick D. Wasserman | Cast | Actor | Lord Infernicus / Boo (voice) | 1 |
 Stephanie Sheh | Cast | Actress | Mai Le (voice) | 1 |
 Troy Baker | Cast | Actor | Krod (voice) | 1 |
 Christian Lanz | Cast | Fernando El Aguirre (voice) | 2 | |
 Isabella Acres | Cast | Actress | Mary-Ann Geerdon / Tiffany / Child #4 / Child #5 (voice) | 1 |
Will Shadley | Cast | Actor | Younger Danny Darrow (voice) | 1 |
 Zach Callison | Cast | Actor | Arthur Baywosenthal/Child #6/Child #7 (voice) | 1 |
David Juskow | Cast | Harry Schnesle-Boysen (voice) | 1 | |
 Phil Idrissi | Cast | Actor | Gabtraf (voice) | 1 |
 David Kaye | Cast | Actor | Argus Fentonpoof (voice) | 1 |
| Person | Type | Job | Role(s) | Episodes |
