| Person | Type | Job | Role(s) | Episodes |
|---|---|---|---|---|
 'Weird Al' Yankovic | Crew | Sound | Theme Song Performance | 1 |
 Adam Reed | Crew | Writing | Writer | 1 |
 Aimee Mann | Crew | Sound | Theme Song Performance | 1 |
 Billy Gibbons | Crew | Sound | Theme Song Performance | 1 |
 Billy Joe Shaver | Crew | Art | Storyboard Artist, Theme Song Performance | 1 |
 Bob Mould | Crew | Sound | Theme Song Performance | 1 |
 Brendon Small | Crew | Sound | Music | 1 |
 Buddy Guy | Crew | Sound | Theme Song Performance | 1 |
 Chuck Leavell | Crew | Sound | Theme Song Performance | 1 |
 Dave Willis | Crew | Writing | Writer, Story, Creator | 131 |
 Dwight Yoakam | Crew | Sound | Theme Song Performance | 1 |
 Fred Schneider | Crew | Sound | Theme Song Performance | 1 |
 George Jones | Crew | Sound | Theme Song Performance | 1 |
 Gillian Welch | Crew | Sound | Theme Song Performance | 1 |
 Jan Hammer | Crew | Sound | Theme Song Performance | 1 |
Jason Reich | Crew | Production | Consulting Producer | 1 |
Jimmie Dale Gilmore | Crew | Sound | Theme Song Performance | 1 |
 John Hiatt | Crew | Sound | Theme Song Performance | 1 |
 John Prine | Crew | Sound | Theme Song Performance | 1 |
 Keith Crofford | Crew | Production | Executive Producer | 132 |
 Lucinda Williams | Crew | Sound | Theme Song Performance | 1 |
Matt Harrigan | Crew | Writing | Writer, Additional Writing | 1 |
 Matt Maiellaro | Crew | Crew | Additional Writing, Creator, Writer | 2 |
 Stephen Malkmus | Crew | Sound | Theme Song Performance | 1 |
 Steve Earle | Crew | Sound | Theme Song Performance | 1 |
 Ted Travelstead | Crew | Production | Consulting Producer | 4 |
 Todd Rundgren | Crew | Sound | Theme Song Performance | 1 |
 William Shatner | Crew | Sound | Theme Song Performance | 1 |
 Willie Nelson | Crew | Sound | Theme Song Performance | 1 |
Bob Pettitt | Crew | Art | Art Department Manager | 20 |
 Casper Kelly | Crew | Crew | Additional Writing, Writer | 2 |
 Johnny Van Zant | Crew | Sound | Theme Song Performance | 1 |
 Jon Wurster | Crew | Production | Consulting Producer | 5 |
Neko Case | Crew | Sound | Theme Song Performance | 1 |
Rich Blomquist | Crew | Production | Consulting Producer | 1 |
Scott Fry | Crew | Visual Effects | Animation Production Assistant | 40 |
Scott Jacobson | Crew | Production | Consulting Producer | 14 |
 Shooter Jennings | Crew | Sound | Theme Song Performance | 1 |
Ted Leo | Crew | Sound | Theme Song Performance | 1 |
Todd Snider | Crew | Sound | Theme Song Performance | 1 |
Will Shepard | Crew | Writing | Writer | 1 |
Elizabeth Cook | Crew | Sound | Theme Song Performance | 2 |
James Galatas | Crew | Crew | Compositors | 56 |
 Amanda Shires | Crew | Sound | Theme Song Performance | 1 |
 Billy Wayne Davis | Crew | Production | Consulting Producer | 4 |
Greg Clancy | Crew | Sound | Theme Song Performance | 1 |
 Jason Isbell | Crew | Sound | Theme Song Performance | 1 |
Shovels & Rope | Crew | Sound | Theme Song Performance | 1 |
 Sturgill Simpson | Crew | Sound | Theme Song Performance | 1 |
Tony DeRosa | Crew | Sound | Theme Song Performance | 1 |
 Jimmy Cliff | Crew | Sound | Theme Song Performance | 1 |
 T-Pain | Crew | Sound | Theme Song Performance | 1 |
 Father John Misty | Crew | Sound | Theme Song Performance | 1 |
 Sharon Van Etten | Crew | Sound | Theme Song Performance | 1 |
 Kate Pierson | Crew | Sound | Theme Song Performance | 1 |
 Cindy Wilson | Crew | Sound | Theme Song Performance | 1 |
Jim Fortier | Crew | Creator | Creator, Writer, Story | |
 David Hidalgo | Crew | Sound | Theme Song Performance | 1 |
Widespread Panic | Crew | Sound | Theme Song Performance | 1 |
Kurt Vile | Crew | Sound | Theme Song Performance | 1 |
 Ty Segall | Crew | Sound | Theme Song Performance | 1 |
Ray Wylie Hubbard | Crew | Sound | Theme Song Performance | 1 |
 Dan Auerbach | Crew | Sound | Theme Song Performance | 1 |
 Yelawolf | Crew | Sound | Theme Song Performance | 1 |
David Rawlings | Crew | Sound | Theme Song Performance | 1 |
 Keith Strickland | Crew | Sound | Theme Song Performance | 1 |
 Lera Lynn | Crew | Sound | Theme Song Performance | 1 |
Jason Ringenberg | Crew | Sound | Theme Song Performance | 1 |
Shawn Coleman | Crew | Sound | Songs, Music | 1 |
Unknown Hinson | Crew | Sound | Theme Song Performance | 1 |
Tony Tidwell | Crew | Sound | Theme Song Performance | 1 |
Dinosaur Jr. | Crew | Sound | Theme Song Performance | 1 |
James Fritz | Crew | Production | Consulting Producer | 4 |
King Khan | Crew | Sound | Theme Song Performance | 1 |
Scott Hilley | Crew | Crew | In Memory Of | 1 |
Jason D. Williams | Crew | Sound | Theme Song Performance | 1 |
Jackyl | Crew | Sound | Theme Song Performance | 1 |
Soilent Green | Crew | Sound | Theme Song Performance | 1 |
Hayes Carll | Crew | Sound | Theme Song Performance | 1 |
Jason D. Williams | Crew | Sound | Theme Song Performance | 1 |
David Lee Powell | Crew | Sound | Original Music Composer | 132 |
Bradley Burch | Crew | Sound | Original Music Composer | 132 |
Billy Joe Shaver | Cast | Actor | Mudsy (voice) | 1 |
 Charles Napier | Cast | Actor | Sheriff (voice) | 6 |
 Coolio | Cast | Actor | Coolio (voice) | 1 |
 Dana Snyder | Cast | Actor | Granny Cuyler (voice) | 132 |
 Danny Baker | Cast | Actor | 85 | |
Dave Willis | Cast | Actor | Narrator / Denny (voice) | 132 |
 David Allan Coe | Cast | Actor | Himself (voice) | 1 |
Edward Hastings | Cast | Ned Hastings (voice) | 1 | |
 Fred Armisen | Cast | Actor | Miguel | 85 |
 Jason 'Wee Man' Acuña | Cast | Actor | Wee Man (voice) | 1 |
 Jesco White | Cast | Actor | Ga-Ga-Pee-Pap Cuyler (voice) | 7 |
 Jonathan Katz | Cast | Actor | Therapist (voice) | 2 |
 Patricia French | Cast | Actress | Aunt Lil (voice) | 132 |
 Patton Oswalt | Cast | Actor | Talking Squid (voice) | 1 |
 Paul Stanley | Cast | Actor | Paul Stanley GPS (voice) | 1 |
 Phil Hendrie | Cast | Actor | (voice) | 1 |
 Tracy Morgan | Cast | Actor | Early Cuyler (voice) | 9 |
 Anthony 'Citric' Campos | Cast | Actor | (voice) | 1 |
 Dan Triandiflou | Cast | Actor | (voice) | 2 |
 Isaac Hayes III | Cast | Actor | (voice) | 1 |
 Lavell Crawford | Cast | Actor | Judge Jammer (voice) | 1 |
 Mary Kraft | Cast | Actress | 85 | |
Todd Hanson | Cast | Actor | 85 | |
Elizabeth Cook | Cast | Actress | Tammy (voice) | 63 |
Jason Isbell | Cast | Actor | Pastor Nubbins (voice) | 29 |
T-Pain | Cast | Actor | T-Pain (voice) | 1 |
Bobby Ellerbee | Cast | Sheriff (voice) | 126 | |
Widespread Panic | Cast | 1 | ||
 Chad Ochocinco | Cast | Actor | Chad Ochocinco (voice) | 1 |
Unknown Hinson | Cast | Actor | 85 | |
Kevin Gillespie | Cast | Actor | Kevin Gillespie (voice) | 1 |
Drive-By Truckers | Cast | 1 | ||
Jason D. Williams | Cast | 1 | ||
Jackyl | Cast | 1 | ||
Jason D. Williams | Cast | 1 | ||
| Person | Type | Job | Role(s) | Episodes |
