| Person | Type | Job | Role(s) | Episodes |
|---|---|---|---|---|
 Katherine Pope | Crew | Production | Executive Producer | |
Liz Heldens | Crew | Production | Executive Producer | 7 |
 Michael Showalter | Crew | Production | Executive Producer, Director | 8 |
 Amanda Seyfried | Crew | Production | Producer | 8 |
 Elizabeth Meriwether | Crew | Production | Executive Producer, Creator, Writer | 8 |
Jordana Mollick | Crew | Production | Executive Producer | |
Liz Hannah | Crew | Production | Executive Producer | |
Taylor Dunn | Crew | Production | Executive Producer | |
Rebecca Jarvis | Crew | Production | Executive Producer | 8 |
Victoria Thompson | Crew | Production | Executive Producer | |
 Alan Ruck | Cast | Actor | Jay Rosan | |
 Anne Archer | Cast | Actress | ||
 Bill Irwin | Cast | Actor | ||
 Ebon Moss-Bachrach | Cast | Actor | John Carreyrou | 1 |
 Elizabeth Marvel | Cast | Actress | Noel Holmes | 5 |
 Hart Bochner | Cast | Actor | Larry Ellison | |
 Joe Nieves | Cast | Actor | Patrick | |
 Kate Burton | Cast | Actress | Rochelle Gibbons | 4 |
 Kevin Sussman | Cast | Actor | ||
 Kurtwood Smith | Cast | Actor | 6 | |
 Laurie Metcalf | Cast | Actress | Phyllis Gardner | 4 |
 LisaGay Hamilton | Cast | Actress | ||
 Mary Lynn Rajskub | Cast | Actress | Lorraine Fuisz | 4 |
 Michael Ironside | Cast | Actor | Don Lucas | 2 |
 Michel Gill | Cast | Actor | Chris Holmes | 5 |
 Naveen Andrews | Cast | Actor | Sunny Balwani | 8 |
 Peter James Smith | Cast | Actor | Gary Yamamoto | |
 Sam Waterston | Cast | Actor | ||
 Stephen Fry | Cast | Actor | 7 | |
 William H. Macy | Cast | Actor | Richard Fuisz | 5 |
Amanda Seyfried | Cast | Actress | Elizabeth Holmes | 8 |
 Amir Arison | Cast | Actor | Avie Tevanian | |
 Bashir Salahuddin | Cast | Actor | Brendan Morris | |
 Dylan Minnette | Cast | Actor | Tyler Shultz | 4 |
 James Hiroyuki Liao | Cast | Actor | Edmond Ku | |
 Rich Sommer | Cast | Actor | Kevin Hunter | |
 Utkarsh Ambudkar | Cast | Actor | Rakesh Madhava | 3 |
 Kate Comer | Cast | Miriam | ||
 Nicky Endres | Cast | Actor | Ana Arriola | |
 Shaun Brown | Cast | Actor | Daniel Young | |
 Mikaya Fisher | Cast | Young Elizabeth Holmes | ||
 Robert Artz | Cast | Derek Cunningham | ||
 Sam Straley | Cast | Christian Holmes | ||
 Jack Buckley | Cast | Actor | Cute Guy | 1 |
 Monroe Cline | Cast | Actress | Stanford Roommate | |
 Gabriel Oliva | Cast | Bored VC | 1 | |
 Jake Satow | Cast | Actor | Christian Holmes Aged 14 | 1 |
Camryn Mi-young Kim | Cast | Erica Cheung | 8 | |
Katie Page | Cast | Patient X | 1 | |
| Person | Type | Job | Role(s) | Episodes |
