| Person | Type | Job | Role(s) | Episodes |
|---|---|---|---|---|
 Gary Hartle | Crew | Directing | Director | 2 |
 Jeph Loeb | Crew | Production | Executive Producer | 103 |
Joe Fallon | Crew | Writing | Writer | 1 |
 Joe Quesada | Crew | Production | Executive Producer | 103 |
Kevin Manthei | Crew | Sound | Music | 103 |
 Paul Dini | Crew | Production | Producer, Writer | 52 |
Rich Fogel | Crew | Writing | Writer | 1 |
 Stan Lee | Crew | Production | Co-Executive Producer | 103 |
 Alan Fine | Crew | Production | Executive Producer | 103 |
Dan Buckley | Crew | Production | Executive Producer | 103 |
James Felder | Crew | Writing | Writer | 2 |
 Brian Michael Bendis | Crew | Production | Consulting Producer | 77 |
 Joe Kelly | Crew | Writing | Writer | 5 |
 Dan Negovan | Crew | Sound | Music Editor | 15 |
Leanne Moreau | Crew | Production | Producer, Line Producer | 26 |
 Adrian Pasdar | Cast | Actor | 52 | |
 Ashley Eckstein | Cast | Actress | Dagger (voice) | 6 |
 Ben Diskin | Cast | Actor | Blood Spider (voice) | 1 |
 Billy West | Cast | Actor | Rocket Raccoon (voice) | 1 |
 Cam Clarke | Cast | Actor | Captain Ultra/Piledriver (voice) | 1 |
 Chi McBride | Cast | Actor | Nick Fury (voice) | 78 |
 Christopher Daniel Barnes | Cast | Actor | Wolf Spider, Spyder-Knight (voice) | 1 |
 Clancy Brown | Cast | Actor | 52 | |
 Clark Gregg | Cast | Actor | Phil Coulson (voice) | 52 |
 Cree Summer | Cast | Actress | Madame Web (voice) | 1 |
 Dante Basco | Cast | Actor | Flash Thompson (voice) | 52 |
 Drake Bell | Cast | Actor | Peter Parker / Spider-Man (voice) | 103 |
 Fred Tatasciore | Cast | Actor | 52 | |
 Greg Cipes | Cast | Actor | Danny Rand / Iron Fist (voice) | 52 |
 J.K. Simmons | Cast | Actor | J. Jonah Jameson (voice) | 103 |
 James Marsters | Cast | Actor | Korvac/Chitauri #3 (voice) | 1 |
 John DiMaggio | Cast | Actor | 52 | |
 Kevin Michael Richardson | Cast | Actor | 52 | |
 Mark Hamill | Cast | Actor | Nightmare / Ox (voice) | 1 |
 Milo Ventimiglia | Cast | Actor | Spider-Man Noir (voice) | 4 |
 Ogie Banks | Cast | Actor | Luke Cage / Power Man (voice) | 103 |
 Peter Lurie | Cast | Actor | Sabretooth/Construction Worker/Announcer (voice) | 1 |
 Quinton Flynn | Cast | Actor | 52 | |
 Rob Paulsen | Cast | Actor | 52 | |
 Robert Clotworthy | Cast | Actor | Captain George Stacy (voice) | 1 |
 Seth Green | Cast | Actor | Rick Jones / A-Bombardier (voice) | 1 |
Stan Lee | Cast | Actor | 52 | |
 Steve Blum | Cast | Actor | Wolverine (voice) | 1 |
 Steven Weber | Cast | Actor | 52 | |
 Tara Strong | Cast | Actress | 52 | |
 Tom Kenny | Cast | Actor | Bentley Wittman | 0 |
 Topher Grace | Cast | Actor | Eddie Brock (voice) | 0 |
 Travis Willingham | Cast | Actor | 52 | |
 Grant George | Cast | Actor | Scott Lang / Ant-Man (voice) | 1 |
 Matt Lanter | Cast | Actor | Harry Osborn (voice) | 52 |
 Troy Baker | Cast | Actor | 52 | |
 Tyler James Williams | Cast | Actor | Prowler (voice) | 52 |
 Cameron Boyce | Cast | Actor | Luke Ross (voice) | 1 |
 Debby Ryan | Cast | Actress | Jessie Prescott (voice) | 1 |
 Logan Miller | Cast | Actor | Sam Alexander / Nova (voice) | 52 |
 Misty Lee | Cast | Aunt May Parker (voice) | 103 | |
 Peyton List | Cast | Actress | Emma Ross (voice) | 1 |
 Skai Jackson | Cast | Actress | Zuri Ross (voice) | 1 |
 Caitlyn Taylor Love | Cast | Actress | Ava Ayala / White Tiger (voice) | 52 |
 Karan Brar | Cast | Actor | Ravi Ross (voice) | 1 |
 Ross Lynch | Cast | Actor | Jack Russell / Werewolf by Night (voice) | 1 |
 Dove Cameron | Cast | Actress | Gwen Stacy, Spider-Gwen (voice) | 1 |
 Max Mittelman | Cast | Actor | Alex O'Hirn / Rhino (voice) | 1 |
 Imari Williams | Cast | Actor | Bone Spider/Goliath Spider (voice) | 2 |
| Person | Type | Job | Role(s) | Episodes |
